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New
Version 2.0 launched 8/20/04
View list of feature updates, changes, and known issues here.

Upcoming
The CCDB is under active development. Several enhancements to the database and related tools are planned in the near future. Efforts are underway to create more advanced query and data input forms that will maximize the benefits offered by the CCDB's rich data model. A feature that outputs data in XML format will also be available. Regular updates will be posted here.


Feedback
If you encounter errors while browsing the site or using the database, please contact the webmaster. Comments about your experience with the CCDB are welcome.
What Is the Cell Centered Database?
The Cell Centered Database (CCDB), launched in 2002 as one of the first Internet databases for cellular imaging data, makes 3D microscopic imaging data available to the structural biology and neuroscience communities. This database houses structural and protein distribution information derived from confocal, multiphoton, and electron microscopy, including correlated microscopy. [more]

What Kind of Data Is Stored in the CCDB?
The CCDB was designed to store and manage cell level information from tissue, cultured cells, and subcellular fractions, regardless of the type of tissue being studied. The CCDB models the entire process of reconstruction, from specimen preparation to segmentation and analysis. [View schema] A volume reconstruction is stored along with pointers to all of the raw images and the processing details required to reconstruct the volume from the raw data. Each object segmented from the 3D volume is stored as a separate object indexed to the parent reconstruction. [more]

Database entities and their descriptions and definitions are listed here.
 
Who Can Access the CCDB?
To view or download data, users must first register here. Registration is free of charge.

To contribute data, researchers must first submit an application. Contact Dr. Maryann Martone for more information.

Who Created the CCDB and Why?
The National Center for Microscopy and Imaging Research (NCMIR) created the CCDB in March 2002 to accommodate high-resolution 3D light and electron microscopic reconstructions.The CCDB also is one of a series of linked and federated databases across multiple biological scales as part of the Biomedical Informatics Research Network (BIRN) project, a National Institutes of Health (NIH) initiative that uses emerging cyberinfrastructure, such as high-speed networks, distributed high-performance computing, and software and data integration capabilities, to foster large-scale biomedical science collaborations. [more]
Sample Data

image of astrocyte
Filled Cells

Purkinje Neuron
Protein Localization

Purkinje Neuron
Correlated LM & EM

Volume
Electron Tomography

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